Table 3 Predicted causal networks explaining observed gene expression differences based on combined HER3-EGFR protein expression.

From: Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers

Master Regulator

Log2FC

Participating regulators

Predicted Activation State

Activation z-score

p-value of overlap

corrected p-value

TXN

−1.93

Ap1, CASP3, CASP8, EGFR, GAPDH, HIF1A, MAPK14, MAPK8, NFkB (complex), NFKB1, NFKBIA, P38 MAPK, PARP1, SMAD3, TP53, TXN

Inhibited

−2.18

1.64E-02

8.80E-03

RTN1

2.05

BCL2L1, BID, CASP3, CASP8, F3, GSK3B, ITPR1, Jnk, Mapk, MAPK8, NFkB (complex), P38 MAPK, Pdi, RTN1, TERT, TP53, UGCG

Activated

2.54

1.77E-02

8.50E-03

TPSD1

−1.33

MAPK1, MAPK14, MAPK3, MAPK8, MAPK9, RARRES2, TPSD1

Inhibited

−2.11

1.82E-02

6.50E-03

HDAC1

−1.28

AR, E2F3, E2F4, EGFR, HDAC1, KDM1A, LEF1, PPARG, RB1, Smad2/3-Smad4, SMAD7, TP53

Activated

3.28

3.56E-02

2.73E-02

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