Figure 3 | Scientific Reports

Figure 3

From: Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes

Figure 3

Stimulation of colony formation by arsenite and oncostatin M (OSM). Values for colony forming efficiency (CFE) from triplicate cultures are given relative to no treatment (NT) or treatment with 2 µM arsenite (As) or 50 ng/ml OSM. Effects of inhibitors of the Erk (U1026, 10 µM) and Stat (Jak Kinase inhibitor 1, 1 µM) pathways are indicated (ERK inh, STAT inh). A representative result is shown. In a compilation of 2–6 experiments with various combinations of conditions, stimulation of CFE compared to NT was highly significant for As and OSM (†p < 0.02) and inhibition of CFE by the Erk inhibitor (*p < 0.02).

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