Figure 4

Cytotoxicity assay of CAL-27 and MCF-7 cancer cells with different concentrations (1–20 μg/mL) of PBS, pGO, pGO-Pt, pGO-DOX, pGO-Pt/DOX, and Pt/DOX mixture. The cell viability of PBS was set as 100%. Relative cell viability of CAL-27 cells for (A) 24 h and (B) 48 h after treatment with pGO, pGO-Pt, pGO-DOX, pGO-Pt/DOX, and Pt/DOX mixture. Relative cell viability of MCF-7 cells for (C) 24 h and (D) 48 h after treatment with pGO, pGO-Pt, pGO-DOX, pGO-Pt/DOX, and Pt/DOX mixture (n = 3). (E) Cellular uptake of DOX-labeled pGO-Pt/DOX and Pt/DOX mixture by CAL-27 human squamous cell carcinoma cell line.