Figure 1 | Scientific Reports

Figure 1

From: The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models

Figure 1

Loss of Sting has limited impact on neuromuscular phenotypes. Locomotor assays analysing climbing ability (negative geotaxis) in (A) young and (B) older adult flies of control and Sting knockdown (RNAi) or null (StingΔRG5) mutants. Charts show mean ± 95% confidence interval (CI); number of animals analysed is shown in each bar. Significance was measured by Kruskal-Wallis test with Dunn’s post hoc correction for multiple comparisons; **p < 0.01, ****p < 0.0001; ns, non-significant. Control genotype is da-GAL4/+. (C) Representative confocal microscopy analysis of mitochondria in flight muscles, immunostained with anti-ATP5A, in control (w1118) and Sting heterozygous and homozygous mutants. Scale bar = 10 µm.

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