Figure 5 | Scientific Reports

Figure 5

From: The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models

Figure 5

Loss of Relish does not rescue Pink1 or parkin mutant phenotypes. (A) Analysis of locomotor (climbing) ability and (B) mitochondrial morphology in young park25 or Pink1B9 mutants combined with Relish knockdown or null mutations. Charts show mean ± 95% confidence interval (CI); number of animals analysed is shown in each bar. Statistical significance was measured by Kruskal-Wallis test with Dunn’s post hoc correction for multiple comparisons; ****p < 0.0001; ns, non-significant. Confocal microscopy images show flight muscle mitochondria immunostained with anti-ATP5A. Scale bar = 10 µm. Control genotypes are da-GAL4/+ for climbing, and w1118 for microscopy. Ctrl RNAi is lacZ-RNAi in the respective mutant background.

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