Table 2 Association of the variable number of tandem repeats of SMYD3 with HBV-related liver diseases.
From: Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma
SMYD3 tandem repeat | HC n = 297 (%) | CHB n = 246 (%) | LC n = 174 (%) | HCC n = 336 (%) | CHB + LC n = 420 (%) | HBV total n = 756 (%) | CHB vs HC | LC vs HC | HCC vs HC | HBV vs HC | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | |||||||
Genotypes | ||||||||||||||
VNTR 2/2 | 21 (7.1) | 14 (5.7) | 6 (3.4) | 7 (2.1) | 20 (4.8) | 27 (3.6) | Reference | Reference | Reference | Reference | ||||
VNTR 2/3 | 64 (21.5) | 37 (15) | 29 (16.7) | 61 (18.2) | 66 (15.7) | 127 (16.8) | 0.75 (0.32–1.76) | 0.5 | 1.8 (0.59–5.6) | 0.3 | 2.7 (0.89–7.92) | 0.079 | 1.2 (0.58–2.44) | 0.6 |
VNTR 3/3 | 212 (71.4) | 195 (79.3) | 139 (79.9) | 268 (79.8) | 334 (79.5) | 602 (79.6) | 1.2 (0.6–2.6) | 0.5 | 2.2 (0.81–6.12) | 0.1 | 2.9(1.07–8) | 0.037 | 1.7 (0.88–3.15) | 0.1 |
Allele | ||||||||||||||
VNTR 2 | 106 (21.7) | 65 (13.2) | 41 (11.8) | 75 (11.2) | 106 (12.6) | 181 (12) | Reference | Reference | Reference | Reference | ||||
VNTR 3 | 488 (78.3) | 427 (86.8) | 307 (88.2) | 597 (88.8) | 734 (87.4) | 1331 (88) | 1.4 (0.97–1.92) | 0.078 | 1.5 (1–2.38) | 0.05 | 1.5 (1–2.14) | 0.05 | 1.4 (1.07–1.86) | 0.017 |
Dominant | ||||||||||||||
VNTR 2/2&2/3 | 85 (28.6) | 51 (20.7) | 35 (20.1) | 68 (20.2) | 86 (20.5) | 154 (20.4) | Reference | Reference | Reference | Reference | ||||
VNTR 3/3 | 212 (71.4) | 195 (79.3 | 139 (79.9) | 268 979.8) | 334 (79.5) | 602 (79.6) | 1.5 (0.99–2.23) | 0.057 | 1.4 (0.88–2.4) | 0.1 | 1.3 (0.86–2.05) | 0.2 | 1.4 (1.02–1.97) | 0.036 |
Recessive | ||||||||||||||
VNTR 2/2 | 21 (7.1) | 14 (5.7) | 6 (3.4) | 7 (2.1) | 20 (4.8) | 27 (3.6) | Reference | Reference | Reference | Reference | ||||
VNTR 2/3&3/3 | 276 (92.9) | 232 (94.3) | 168 (96.6) | 329 (97.9) | 400 (95.2) | 729 (96.4 | 1.1 (0.55–2.35) | 0.7 | 2.2 (0.8–6.02) | 0.1 | 2.9 (1.07–8.03) | 0.036 | 1.6 (0.82–2.94) | 0.2 |
