Figure 5 | Scientific Reports

Figure 5

From: PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs

Figure 5

Gene set enrichment analysis of genes affected by PDCD4 knockdown. (a) Examples of GSEA charts revealing the role of PDCD4 in cell cycle regulation. (b) GO-term (biological process) enrichment analysis of genes up- and downregulated by PDCD4 silencing. Significantly differentially expressed gene sets were identified by GSEA and reduced to most significant terms by REVIGO. Positive and negative enrichment scores, respectively, indicate up- and down-regulation in PDCD4 knockdown cells. Numbers indicate counts of genes in each gene set. The asterisks indicate FDR q-values (*<0.05; **<0.01; ***<0.001; ****<0.0001; ***** < 0.00001).

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