Table 1 The binding kinetics of GB235 determined by biacore.

From: A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivo

 

ka (1/Ms)

kd (1/s)

KD (M)

Rmax (RU)

Chi² (RU²)

Human HER2

3.70 × 105

6.25 × 10−4

1.69 × 10−9

49.11

1.8

Cynomolgus HER2

3.53 × 105

7.68 × 10−4

2.18 × 10−9

51.76

5.12

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