Figure 3 | Scientific Reports

Figure 3

From: Novel Strain of the Chronic Wasting Disease Agent Isolated From Experimentally Inoculated Elk With LL132 Prion Protein

Figure 3

Microscopic changes in the hippocampus (a–c, g,h) and cerebellum (d–f, i) of cervidized mice inoculated with brain material from LL132 (a,d), LM132 (b,e) or MM132 (c,f) CWD-affected elk. Graphs depict the severity of vacuolation in the CA1 area (g) and dentate gyrus (h) of the hippocampus, and magnitude of reduction of granule cells in the cerebellum (i). Error bars reflect the SEM (standard error of the mean). Statistically significant differences are indicated by column labels that do not share the same letters. All mice express M132 elk prion protein; LL/LM/MM indicates prion protein genotype of the elk donors for the first passage study i.e. LL132, LM132 and MM132 respectively; P1, first passage (elk to mouse); P2, second passage (mouse to mouse). All photomicrographs original magnification 10×.

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