Table 2 Summary of [GdnHCl]1/2 values for each mouse group.

From: Novel Strain of the Chronic Wasting Disease Agent Isolated From Experimentally Inoculated Elk With LL132 Prion Protein

Mouse Group

[GdnHCl]1/2 values

Normalized to 0.25 M

Normalized to 1 M

LL-P1

3.4 ± 0.2a

3.1 ± 0.1e

LM-P1

2.2 ± 0.2bc

2.0 ± 0.2fg

MM-P1

2.2 ± 0.04bc

2.1 ± 0.1fg

LL-P2b

2.1 ± 0.2bc

2.2 ± 0.1fg

LM-P2a

2.6 ± 0.1c

2.5 ± 0.1f

LM-P2b

2.1 ± 0.06b

1.8 ± 0.04g

MM-P2

2.4 ± 0.06c

2.1 ± 0.07fg

  1. [GdnHCl]1/2 is defined as the concentration of GdnHCl at which the PrPSc signal was reduced by half of the signal at the normalization concentration (0.25 M or 1 M GdnHCl). [GdnHCl]1/2 values were determined for each individual mouse and numbers presented in the table reflect mean values for all mice tested in each group + /− the standard error of the mean. For groups with shared superscripts within a column, differences between the means (as assessed by the Games-Howell post-hoc test) were not significant (P < 0.05). Note that since 0.25 M and 1 M values were analyzed separately, different superscripts between the two columns do not indicate assessment of differences across columns.
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