Table 3 Associations of tau and Aβ pathologies with total (Iba1) and activated (CD68) microglia in APOE ε4 negative and positive participants.

From: Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype

AT8 a

ε4 Negative

ε4 Positive

B

95% CI

p-value

B

95% CI

p-value

Iba1

0.002

−0.002–0.005

0.398

0.013

0.006–0.020

0.001*

CD68

0.001

−0.002–0.004

0.496

0.002

−0.004–0.007

0.525

Aβ1–42b

OR

95% CI

p-value

OR

95% CI

p-value

Iba1

1.003

0.995–1.011

0.449

0.993

0.979–1.006

0.288

CD68

1.003

0.998–1.009

0.271

0.995

0.987–1.004

0.257

Aβ1–40b

OR

95% CI

p-value

OR

95% CI

p-value

Iba1

1.006

0.998–1.014

0.124

1.012

0.998–1.027

0.093

CD68

1.003

0.998–1.009

0.229

1.005

0.996–1.014

0.251

  1. aMultiple linear regressions were used to assess relationship of Iba1 and CD68 with AT8 cellular density adjusting for age, sex, and Aβ1–42. bOrdinal logistic regressions were used to assess relationship of Iba1 and CD68 with Aβ adjusting for age and sex OR, odds ratio; CI, confidence interval. *p < 0.05 after Bonferroni correction for multiple comparisons.
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