Table 1 Characteristics of sample by urinary 8-OHdG and F2-isoprostane predicted mean (95% Confidence Interval) concentrations over time.

From: Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study

 

Total (N = 618)

8-OHdG (N = 2,377)a (ng/mg Cr)

F2-isoprostane (N = 1,243) (ng/mg Cr)

N (%)

Predicted mean (95% CI)

Predicted mean (95% CI)

All

618 (100)

58.3

55.9

60.8

6.5

5.9

7.2

Sex

   Female

224 (36.3)

60.8

56.7

65.3

6.0

5.0

7.1

   Male

394 (63.8)

56.9

53.9

60.0

6.9

6.0

7.8

Race/Ethnicity

   White

360 (58.3)

63.8

60.5

67.3

6.9

6.0

7.9

   Black

102 (16.5)

43.7

39.4

48.5*

4.9

3.8

6.4*

   Hispanic

85 (13.8)

55.1

49.3

61.6*

6.4

4.9

8.5

   Multiracial/Other

71 (11.5)

58.0

51.3

65.5

7.2

5.3

9.8

Age (years) at visit 1

   ≤8

171 (27.7)

83.5

78.0

89.3

8.6

7.1

10.4

   >8-<13

219 (35.4)

61.1

57.5

64.8*

7.3

6.2

8.7

   ≥13

228 (36.9)

42.0

39.5

44.6*

4.4

3.7

5.2*

Type of kidney disease

   Non-Glomerular

551 (89.2)

60.1

57.6

62.8

6.8

6.1

7.6

   Glomerular

67 (10.8)

43.5

38.0

49.8*

4.2

3.0

6.0*

Urinary cotinine (ng/mL) at visit 1

   <20

516 (96.6)

58.8

56.2

61.5

6.5

5.9

7.3

   ≥20

18 (3.4)

47.6

37.5

60.5

8.4

4.4

16.1

Body mass index z-score at visit 1

   <0

216 (36.1)

61.1

57.2

65.2

6.8

5.8

8.0

   ≥0-≤1

193 (32.3)

58.0

55.6

60.5

6.4

5.8

7.1

   >1

189 (31.6)

55.1

51.4

59.1*

6.1

5.1

7.2

eGFR (ml/min/1.73 m2) at visit 1

   ≥90

25 (4.1)

69.3

61.9

77.6

5.1

3.9

6.7

   ≥60-<90

165 (26.9)

62.8

59.0

66.8

5.9

5.1

6.8

   ≥30-<60

337 (54.9)

56.9

54.4

59.5

6.8

6.0

7.6

   <30

87 (14.2)

51.5

47.4

56.1*

7.8

6.2

9.7

Urinary protein to creatinine ratio (mg/dL:mg/dL) at visit 1

   <0.2

239 (40.3)

57.8

54.2

61.6

6.0

5.2

7.0

   ≥0.2-≤2

294 (49.6)

58.1

55.4

61.0

6.7

6.0

7.6

   >2

60 (10.1)

58.4

52.9

64.6

7.5

5.8

9.8

SBP Z-score at visit 1

   <0

224 (39.1)

56.3

52.5

60.3

6.0

5.1

7.1

   ≥0

349 (60.9)

60.4

57.1

63.9

6.8

5.9

7.8

DBP Z-score at visit 1

   <0

175 (30.5)

53.2

49.2

57.5

6.0

4.9

7.2

   ≥0

398 (69.5)

61.4

58.3

64.7*

6.7

5.9

7.6

Hypertensive over follow-up

   No

403 (66.0)

57.2

54.3

60.3

6.1

5.4

7.0

   Yes

208 (34.0)

61.0

56.7

65.5

7.3

6.1

8.7

Antihypertensive medication use over follow-up

   No

167 (27.0)

65.7

60.6

71.3

6.3

5.1

7.6

   Yes

451 (73.0)

55.8

53.1

58.6*

6.6

5.9

7.5

  1. Abbreviations: 8-OHdG: 8-OH deoxyguanosine; Cr: creatinine; CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; CI: confidence interval.
  2. aThere is a discrepancy between the total number of observations in the study (N = 2,464) due to 87 samples missing data on creatinine.
  3. *Significant difference (p < 0.05) in 8-OHdG or F2-isoprostane concentrations in the respective category compared with the reference (the first row listed for each covariate except for body mass index z-score where the reference is ≥0-≤1) from linear mixed models with a random intercept.
Back to article page