Figure 1 | Scientific Reports

Figure 1

From: Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels

Figure 1

Acute seizure induction in Kcnt1−/− mice and age-matched wild type controls. (a) Threshold stimulus current to evoke a tonic hindlimb extension seizure. Seizure thresholds are reduced in Kcnt1−/− mice compared to wild type (p =< 0.01, Student’s t test). (b) Electroshock seizure survival at high stimulus intensities. Seizures induced by these high currents were associated with high mortality in wild type animals, while Kcnt1−/− mice were relatively protected (Pearson’s χ2 < 0.01). (c) Latency to convulsive seizures (generalized clonus, rearing and falling, or uncontrolled jumping) following administration of PTZ 60  mg/kg i.p. No differences were observed either in time to seizures (p = 0.27, log rank test) or in observations in the pattern and intensity of seizures.

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