Figure 3

Left hemispheric channel (upper panel) of 24-hour EEG recording from a Kcnt1+/R455H heterozygous mouse demonstrating three spontaneous seizures. Multiple seizures types were seen including (a) falling with tonic-clonic movements, (b) subclinical seizures or possible brief behavioral arrest, and (c) myoclonic seizure. No seizures or interictal discharges were seen in the corresponding wild type littermates (N = 4) or in Kcnt1−/− animals (N = 4) in 72 hours of recording.