Figure 7 | Scientific Reports

Figure 7

From: Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen

Figure 7

Effect of short-term ibuprofen treatment (7 days) on levels of oxidative-stress related proteins in control and ibuprofen-treated mouse livers. Change in levels of protein associated with oxidative stress, GSTT2 (Glutathione S-transferase theta-2), GSTMI (Glutathione S-transferase mu 1), and GSTA1/2/5 (Glutathione S-transferase alpha 1/2/5) obtained by mass spectrometry (A). Western blot analysis was performed to determine the expression levels of protein associated with oxidative stress, GSTT2, GSTMI, and GSTA1/2/5 in (B) Male mouse livers, and (C) Female mouse livers. Band signal intensities were analyzed by Image Lab® Software Version 12 and normalized with intensities obtained from loading control after staining with commercial Ponceau S for total protein. Value are mean ± SE; n = 4–6 per group. *p < 0.05.

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