Scientific Reports

Table 1 Expression pattern of significantly regulated miRNAs.

From: Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation

miRNA name		mean CPM				log₂FC XXL vs. native USSC
miRNA name		native USSC	3d XXL USSC	7d XXL USSC	14d XXL USSC	3d XXL	7d XXL	14d XXL
downregulated miRNAs	hsa-miR-222-3p	18723	6440	6377	4381	−1.5	−1.6	−2.1
	hsa-miR-221-5p *	4066	566	403	594	−2.8	−3.3	−2.8
	hsa-miR-484	2156	530	265	1385	−2.0	−3.0	−0.6
	hsa-miR-24-2-5p	1096	285	167	310	−1.9	−2.7	−1.8
	hsa-miR-335-5p	1078	252	189	203	−2.1	−2.5	−2.4
	hsa-miR-335-3p	284	119	49	34	−1.3	−2.5	−3.1
	hsa-miR-27a-5p *	281	43	61	67	−2.7	−2.2	−2.1
	hsa-miR-431-5p	231	82	73	48	−1.5	−1.7	−2.3
	hsa-miR-222-5p	210	25	24	18	−3.1	−3.1	−3.6
	hsa-miR-138-1-3p	203	52	42	13	−2.0	−2.3	−3.9
	hsa-miR-17-5p	149	99	64	47	−0.6	−1.2	−1.7
	hsa-miR-1185-1-3p	104	37	55	22	−1.5	−0.9	−2.2
	hsa-miR-424-5p	101	41	21	21	−1.3	−2.3	−2.3
upregulated miRNAs	hsa-miR-146a-5p	7218	57295	60493	55211	3.0	3.1	2.9
	hsa-miR-191-5p	15298	29437	45496	47388	0.9	1.6	1.6
	hsa-let-7i-5p	24212	43439	76470	44284	0.8	1.7	0.9
	hsa-miR-34a-5p *	522	5372	5849	8076	3.4	3.5	4.0
	hsa-miR-23b-3p	2178	2675	3652	5662	0.3	0.7	1.4
	hsa-miR-132-3p	187	523	1278	706	1.5	2.8	1.9
	hsa-miR-7706	91	267	303	430	1.6	1.7	2.2
	hsa-miR-425-5p	203	277	1020	412	0.5	2.3	1.0
	hsa-miR-328-3p	61	109	231	312	0.8	1.9	2.3
	hsa-miR-212-5p	24	117	155	156	2.3	2.7	2.7
	hsa-miR-1180-3p	55	85	285	155	0.6	2.4	1.5
	hsa-miR-212-3p	48	171	243	153	1.8	2.3	1.7
	hsa-miR-182-5p	43	87	188	144	1.0	2.1	1.7
	hsa-miR-3605-3p	25	57	101	144	1.2	2.0	2.5
	hsa-miR-132-5p	21	57	171	60	1.5	3.0	1.5

Summary of miRNAs downregulated from a mean CPM value >100 (upper part of the table) and upregulated to a mean CPM value >100 at any time point of XXL incubation (lower part of the table). In XXL-USSC, 13 miRNAs were downregulated from a mean CPM value > 100 from which five miRNAs were significantly reduced at all three investigated time points of XXL incubation (hsa-miR-221-5p, hsa-miR-24-2-5p, hsa-miR-27a-5p, hsa-miR-222-5p, hsa-miR-138-1-3p). From 15 miRNAs induced in XXL-USSC, three miRNAs (hsa-miR-146a-5p, hsa-miR-34a-5p, hsa-miR-212-5p) were significantly upregulated at all investigated time points of XXL incubation. Numbers indicate the corresponding mean CPM values for the respective miRNAs at the four time points. Expression changes are shown as log₂FC values at the right side. Log₂ fold values in italics indicate significant expression changes. The miRNAs with * were used for transfection experiments.

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