Figure 1 | Scientific Reports

Figure 1

From: Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail

Figure 1

Conformational changes on binding of fatty acids to AeOBP22 (a) Region of the 1H-15H HSQC of apo-AeOBP22 (blue) and bound to nonadecanoic acid (red). (b) Plot of normalized chemical shift changes between apo-AeOBP22 and bound to C19 fatty acid. Significant chemical shift changes are color coded as greater than 1 s.d. above the mean (orange) and 2 s.d. above the mean (red). Horizontal dashed lines indicate the position of the mean, +1.sd. and +2 s.d. from bottom to top. The location of the α-helical regions is shown as blue cylinders below. (c) Plot of secondary structure propensity scores (SSP)41 for apo AeOBP22 (blue) and the complex with C19 (red). (d) Plot of NMR 15N R2 relaxation rates for apo (blue) and bound to arachidonic acid (red) recorded at a 1H frequency of 900 MHz. Error bars are shown in black.

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