Figure 2 | Scientific Reports

Figure 2

From: Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail

Figure 2

Structure of AeOBP22. (a) Ribbon diagram of the AeOBP22-linoleic acid complex solved by X-ray crystallography at 1.85 Å. Helices are color coded from blue to red, N to C terminus. The binding pocket is shown as a surface representation and linoleic acid is shown as sticks. (b) Comparison of the C-terminal tail in the linoleic acid complex (yellow) and in the apo-state (blue). In apo AeOBP22, L115 and F108 insert into the pocket (shown in grey) to occlude binding of larger ligands. Reside numbers for the apo-state are preceded with an “a”. Residues 118–123 of the apo-state are not observable in the crystal.

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