Figure 5 | Scientific Reports

Figure 5

From: The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition

Figure 5

Hyperactive behavior in FAM19A1 −/− mice. (A) Time in the open arm (F(2, 32) = 6.469, p = 0.0044) and (B) total distance (F(2, 32) = 7.803, p = 0.0017) were measured in the elevated plus maze (EPM) test in WT (n = 15), FAM19A1 +/− (n = 11) and FAM19A1 −/− (n = 9) mice. (C) Time in the center and (D) total distance (F(2, 43) = 14.50, p < 0.0001) were measured in the open field test (OFT) in WT (n = 19), FAM19A1 +/− (n = 9) and FAM19A1 −/− (n = 18) mice. (E) Simple line tracings of movements in the OFT arena. (F) Percentage of immobile time (F(2, 36) = 5.478, p = 0.0084) on the tail suspension test (TST) in WT (n = 17), FAM19A1 +/− (n = 11) and FAM19A1 −/− (n = 11) mice. (G) Spontaneous alteration and (H) total distance (F(2, 34) = 8.257, p = 0.0012) on the Y-maze in WT (n = 16), FAM19A1 +/− (n = 9) and FAM19A1 −/− (n = 12) mice. Data are presented as means ± standard errors of the means (SEM). *p < 0.05, **p < 0.01, ***p < 0.001 vs WT or FAM19A1 +/− by one-way analysis of variance (ANOVA) with Bonferroni post hoc tests.

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