Figure 7

Fear responses in FAM19A1 −/− mice. (A–C) Pavlovian fear conditioning test. (A) Fear conditioning during the acquisition phase; F(1, 85) = 53.68, p < 0.0001 across genotypes. (B) Contextual and (C) auditory memory tests were performed 24 h after the acquisition phase in WT (n = 9), and FAM19A1 −/− (n = 8) mice. (D) The innate fear test was performed using synthetic fox feces odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) in WT (n = 8) and FAM19A1 −/− (n = 10) mice. Data are presented as means ± standard errors of the means (SEM). *p < 0.05, **p < 0.01, ***p < 0.001 versus WT by two-way analysis of variance (ANOVA) with Bonferroni post hoc test or Student’s t test.