Figure 1 | Scientific Reports

Figure 1

From: T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management

Figure 1

Flow cytometry analysis. (a) Representative flow cytometry plot for naïve (circle, CD45RBhigh/CD45RA+/CD62L+), IRC (dotted box CD45RA+/CD62L-) and Treg (grey circle FoxP3+/CD25+/CD127−) following gating on CD3+ CD4+ T-cells. Difference between health and RA are highlighted for naïve/IRC subsets. (b) Established age relationship in 120 healthy controls for naïve and Treg CD4+ T-cells. [expected naïve] = −0.63 ×[age] +66.6 (rho = 0.850, p < 0.0001); [expected Treg] = +0.061 ×[age] +1.83 (rho = 0.554, p = 0.001). IRC were not related to age. IRC were considered high when above the 95% CI of distribution (set at 4%).

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