Figure 2
Effective tumor targeting by KST0650. CT26 cancer cell-bearing mice were injected i.p. with 1 × 106 cfu KST0650. (a) The numbers of KST0650 in CT26 tumors of BALB/c mice were calculated for 14 days. (b) Immunofluoresence assay was used to visualize the tumor-targeting ability of KST0650 in CT26 tumor tissues. The nuclei of CT26 tumor cells were stained with DAPI (blue) and the Salmonella strains were stained with FITC-conjugated anti-Salmonella rabbit IgG (green). White arrows indicate KST0650 strain. Representative images are shown; original magnification in the left panel, 40×; original magnification in the right panel, 80×. Bacterial fluorescence signals in tumor. Data are fluorescence intensities (a.u.) ± SEM of KST0650 and asterisks (*) indicate significant difference between each group (**P < 0.01).
