Table 2 Multiple regression analysis of the annual eGFR reduction rate.

From: DNA damage and expression of DNA methylation modulators in urine-derived cells of patients with hypertension and diabetes

 

Log DNMT1/AQP1

Log DNMT3A/AQP1

Log DNMT3B/AQP1

Coefficient (95% CI)

p value

Coefficient (95% CI)

p value

Coefficient (95% CI)

p value

Model A

1.46 (0.42 to 2.5)

P = 0.0076

1.18 (0.16 to 2.19)

P = 0.024

1.44 (0.45 to 2.42)

P = 0.058

Model B

1.51 (0.43 to 2.6)

P = 0.008

1.2 (0.15 to 2.25)

P = 0.027

1.47 (0.45 to 2.49)

P = 0.0065

Model C

1.19 (0.22 to 2.15)

P = 0.0178

0.98 (0.064 to 1.89)

P = 0.0368

1.10 (0.17 to 2.04)

P = 0.0223

  1. Model A: multiple linear regression model for the annual eGFR reduction rate adjusted by age and baseline eGFR.
  2. Model B: multiple linear regression model for the annual eGFR reduction rate adjusted by age, baseline eGFR and the presence of diabetes.
  3. Model C: multiple linear regression model for the annual eGFR reduction rate adjusted by age, baseline eGFR, the presence of diabetes and the amount of albuminuria.
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