Figure 3
Loss of ribonuclease activity of ANG variants does not correlate with ALS onset. Spearman’s Coefficient (p value 0.340) and Kendall Tau’s coefficient (p value 0.294) were used for analyzing correlation. Kaplan-Meier survival analysis was performed and the statistical significance of differences in survival between the categories was evaluated using Log-rank (p value 0.235), Breslow (p value 0.119), and Tarone-ware (p value 0.173) tests. A significance level of 0.05 was used. (a) Scatter plot demonstrating no significant correlation between ribonuclease activity and ALS onset. Sizes of points are proportional to number of cases. (b) Kaplan-Meier curves illustrating no significant differences in ALS onset between patients with ANG variants with %WT ribonuclease activity less than or equal to 10% and variants with %WT ribonuclease activity greater than −10%.
