Table 5 Kaplan-Meier curves’ log rank, Breslow and Tarone-ware tests are used to evaluate statistical equivalence in ALS onset, disease duration and lifespan of ANG variants with ∆∆G less than or equal to −1 and variants with ∆∆G greater than −1 or relative (WT) ribonuclease activity less than or equal to 10% or ribonuclease activity greater than 10%.
Physicochemical property | Log-rank | Breslow | Tarone-Ware | ||||
|---|---|---|---|---|---|---|---|
Chi-Square | p value | Chi-Square | p value | Chi-Square | p value | ||
ALS Onset | Stability | 3.72 | 0.054 | 5.93 | 0.015* | 4.89 | 0.027* |
ALS Onset | Ribonuclease Activity | 1.41 | 0.235 | 2.43 | 0.119 | 1.86 | 0.173 |
Disease Duration | Stability | 3.23 | 0.072 | 2.94 | 0.086 | 3.14 | 0.077 |
Disease Duration | Ribonuclease Activity | 9.65 | 0.002* | 6.72 | 0.01* | 8.02 | 0.005* |
