Table 3 Summary of the association between MIR499A rs3746444 polymorphism and breast cancer susceptibility.
From: Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis
Comparison model | No. of studies | No. of cases | No. of controls | Effect model | OR (95% CI) | P |
|---|---|---|---|---|---|---|
Homozygous model | ||||||
Overall | 14 | 4,704 | 6,085 | Random | 1.33 (1.03–1.71) | 0.03 |
Asian | 10 | 2,147 | 2,420 | Random | 1.45 (1.01–2.07) | 0.04 |
Caucasian | 3 | 1,363 | 2,219 | Fixed | 1.04 (0.79–1.37) | 0.79 |
High quality | 8 | 4,097 | 5,367 | Fixed | 1.28 (1.09–1.51) | <0.01 |
Low quality | 6 | 607 | 718 | Random | 1.23 (0.60–2.53) | 0.57 |
Heterozygous model | ||||||
Overall | 14 | 6,337 | 8,117 | Fixed | 1.08 (1.00–1.16) | 0.04 |
Asian | 10 | 2,825 | 3,088 | Fixed | 1.18 (1.05–1.32) | <0.01 |
Caucasian | 3 | 1,925 | 3,073 | Fixed | 1.04 (0.92–1.18) | 0.48 |
High quality | 8 | 5,490 | 7,205 | Fixed | 1.07 (0.99–1.15) | 0.11 |
Low quality | 6 | 847 | 912 | Random | 1.24 (0.86–1.79) | 0.26 |
Dominant model | ||||||
Overall | 14 | 6,797 | 8,534 | Random | 1.15 (1.02–1.30) | 0.03 |
Asian | 10 | 3,121 | 3,291 | Random | 1.24 (1.02–1.50) | 0.03 |
Caucasian | 3 | 2,019 | 3,215 | Fixed | 1.04 (0.93–1.17) | 0.47 |
High quality | 8 | 5,816 | 7,533 | Fixed | 1.09 (1.02–1.18) | 0.02 |
Low quality | 6 | 981 | 1,001 | Random | 1.27 (0.86–1.88) | 0.23 |
Recessive model | ||||||
Overall | 14 | 6,797 | 8,534 | Random | 1.35 (1.06–1.72) | 0.01 |
Asian | 10 | 3,021 | 3,141 | Fixed | 1.60 (1.32–1.93) | <0.01 |
Caucasian | 3 | 2,019 | 3,215 | Fixed | 1.02 (0.77–1.33) | 0.91 |
High quality | 8 | 5,816 | 7,533 | Fixed | 1.16 (0.99–1.37) | 0.07 |
Low quality | 6 | 981 | 1,001 | Random | 1.78 (1.03–3.08) | 0.04 |
Allele model | ||||||
Overall | 14 | 13,594 | 17,068 | Random | 1.12 (1.00–1.26) | 0.04 |
Asian | 10 | 6,242 | 6,582 | Random | 1.17 (0.98–1.40) | 0.08 |
Caucasian | 3 | 4,038 | 6,430 | Fixed | 1.03 (0.94–1.14) | 0.52 |
High quality | 8 | 11,632 | 15,066 | Fixed | 1.11 (1.04–1.17) | <0.01 |
Low quality | 6 | 1,962 | 2,002 | Random | 1.11 (0.78–1.58) | 0.56 |
