Figure 1
From: Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations
(a) Density of PubMed IDs (PMIDs) per gene for all prognostic unfavorable genes in various types of cancer from the Human Protein Atlas; the bulk of genes have few articles and the density begins to decrease sharply at 100. Genes with ≤50 PMIDs are defined as functionally enigmatic genes; and genes with number of PMIDs >50 are considered well-studied genes. (b,c) Distribution of autosomal dominant and recessive disease associations among functionally enigmatic genes and well-studied genes. (d,e) Distribution of primate-specific genes and conserved eukaryotic genes among functionally enigmatic genes and well-studied genes.
