Figure 4 | Scientific Reports

Figure 4

From: High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia

Figure 4The alternative text for this image may have been generated using AI.

Correlation of high WBP5 expression with HOXA and HOXB clusters gene signatures. (A) Volcano plots indicating the most differentially more highly (red dots, above 1.5 log2 FC) and lowly expressed genes (blue dots, below −1.5 log2 FC) in the GSE6891 (Verhaak), GSE15434 (Kohlmann), GSE13204 (Haferlach), GSE1159 (Valk) and GSE22845 (Taskesen) datasets. The most highly differentially expressed HOXA, HOXB and HOX-TALE genes are indicated in each plot. (B) Gene Set Enrichment Analysis (GSEA) plots show enrichment of HOXA and HOXB clusters genes ranked using a signal-to-noise metric according to expression in WBP5 low versus high expressers.

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