Figure 1

Body weight change of female and male mice receiving normal diet (ND) (A,B) or high fat (C,D) diet (HFD). Female and male mice, ND and HFD groups were analyzed separately. The animal numbers in the experimental groups were as followes: n = 7 in male ND AL KO, HFD TR WT and HFD AL KO; n = 8 in female ND TR WT, HFD TR KO, HFD AL WT, HFD AL KO and in males in the ND TR WT, ND TR KO, ND AL WT, HFD TR KO and HFD AL WT. N = 9 was used in female ND TR KO, ND AL WT and ND AL KO; n = 10 in female HFD TR WT. *p < 0.05; **p < 0.01; ***p < 0.001 difference according to Šidákś test between WT and KO in the TR (grey symbols) and AL (light blue) groups. ⁺p < 0.05; ⁺⁺p < 0.01; ⁺⁺⁺p < 0.001 difference between TR and AL groups according to Šidákś test in WT (black or dark blue) or KO (grey or light blue) mice. Symbols represent means, whiskers SEM.