Table 3 Overview of the differences between WT and KO.

Diet	Sex	Regime	Weight gain	Food intake	Blood glucose	NPY	Orexin
ND	female	AL	normal	decreased	increased	decreased	decreased
	female	TR	normal	normal	normal	normal	normal
	male	AL	normal	normal	normal	normal	normal
	male	TR	increased	normal	normal	normal	normal
HFD	female	AL	normal	normal	normal	normal	decreased
	female	TR	increased	normal	increased	normal	normal
	male	AL	increased	normal	normal	decreased	decreased
	male	TR	increased	normal	normal	decreased	normal

Normal: no statistical difference between WT and KO. Increased: significantly higher values in KO compared to WT. Decreased: significantly lower values in KO compared to WT.

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