Figure 4 | Scientific Reports

Figure 4

From: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants

Figure 4The alternative text for this image may have been generated using AI.

Generalization performance of the melancholic MDD biomarker to other subtypes and psychiatric disorders. To assess the difference in density distributions of WLS, Benjamini–Hochberg-corrected Kolmogorov–Smirnov test was applied to the comparison between each disorder and its healthy control. (a) Melancholic MDD (Mel. MDD) and healthy control (HC) were significantly different in density distribution of WLS (p = 6.3 ×   10–14). For other subtypes of MDD and psychiatric disorders, there was no significant difference was observed when the melancholic MDD classifier was applied; (b) non-melancholic MDD (Non Mel. MDD) and HC (p = 0.14), (c) treatment-resistant MDD (Treat. Res. MDD) and HC (p = 0.81), (d) autism and HC (p = 0.97), and (e) schizophrenia and HC (p = 0.08). ***p < 0.001.

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