Table 2 Identified 10 FCs for the melancholic MDD classifier.

From: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants

ID

Name

Lat.

BSA atlas (Sulcus)

BA

r MDD

r HC

Weight

Contribution

1

Inferior Frontal Gyrus opercular part

L

Diagonal ramus of the lateral fissure

44

−0.018

0.173

−5.17

0.987

 

Dorsomedial Prefrontal Cortex, Supplementary Motor Area: SMA, Pre-SMA, Frontal Eye Fields

R

Median frontal sulcus

6, 8, 9

2

Dorsolateral Prefrontal Cortex, Middle Frontal Gyrus

L

Intermediate frontal sulcus

46

0.123

−0.065

5.20

0.978

 

Posterior Cingulate Cortex, Precuneus

L

Internal parietal sulcus

7, 23, 31

3

Thalamus

L

Thalamus

—

0.050

0.208

−3.27

0.517

 

Anterior Cingulate Cortex, Posterior Cingulate Cortex

R

Subcallosal sulcus

23, 24, 33

4

Inferior Frontal Gyrus Triangular part

L

Inferior frontal sulcus

45

0.286

0.407

−3.75

0.454

 

Inferior Frontal Gyrus opercular part

R

Inferior precentral sulcus

44, 6

5

Lingual Gyrus

L

Anterior intralingual sulcus

18

0.166

0.072

4.08

0.384

 

Middle Occipital Gyrus

R

Lobe occipital

19

6

Caudate

L

Caudate

—

−0.167

−0.067

−2.97

0.297

 

Cuneus

L

Cuneal sulcus

18

7

Lingual Gyrus

L

Posterior intra-lingual sulcus

18

0.251

0.078

1.52

0.263

 

ParaHippocampus, Fusiform Gyrus

R

Collateral fissure

30,37

8

Middle Cingulate Cortex

L

Calloso-marginal posterior fissure

23

−0.073

−0.168

2.68

0.255

 

Calcarine

L

Occipito-polar sulcus

17

9

Inferior Temporal Gyrus

L

Median occipito-temporal lateral sulcus

20

−0.093

0.015

−1.41

0.152

 

Post Central Gyrus

L

Central sulcus

3

10

Inferior Temporal Gyrus

L

Median occipito-temporal lateral sulcus

20

0.053

0.135

−1.03

0.084

 

Superior Parietal Gyrus

R

Superior parietal sulcus

7

  1. The averaged functional correlation value of MDDs (rMDD) and HCs (rHC) are shown for each FC. As the patient group was always the positive class in the classifier, the sign of weight was positive when rMDD > rHC, and negative when rMDD < rHC. Contribution was calculated as (rMDD - rHC) × weight.