Table 1 Tenatoprazole Susceptibility of Viruses Unrelated to HIV.

From: Selective Targeting of Virus Replication by Proton Pump Inhibitors

Virus

Cell line

Budding Site

Virus Production

Component Assayed

Assay

DENV

293 T

Endoplasmic reticulum

Resistant

Infectivity

FFU

EBOV

HeLa

Plasma membrane

Susceptible (1.6)

GP protein

IS

EBV

CLIX-FZ

Nuclear membrane

Susceptible (~4)

BALF5

qPCR

HIV-1

293 T

Plasma membrane

Susceptible (2)

Gag p24

WB

MAYV

293 T

Plasma membrane

Susceptible (2.5)

Infectivity

PFU

PV

293 T

None

Resistant

Infectivity

PFU

ZIKV

293 T

Endoplasmic reticulum

Resistant

Infectivity

PFU

  1. Tenatoprazole susceptibility was assessed for each virus using an assay standard for the field. Abbreviations are: focus forming units (FFU), immunostain (IS), quantitative PCR (qPCR), Western blot (WB), and plaque forming units (PFU). Virus production was determined as resistant or susceptible, with selectivity Index indicated in parentheses. Selectivity index is defined as the ratio of cytotoxic concentration to effective concentration (CC50/EC50). CC50 is the compound’s concentration (µM) required for the reduction of cell viability by 50%; EC50 is the compound’s concentration (µM) required for the reduction in the assay of virus production by 50%.
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