Table 2 Chemical Shift Perturbations and Broadened Peaks Observed Upon Prazole Binding to Tsg101.

Tenatoprazole	Esomeprazole	Pantoprazole	Rabeprazole	Lansoprazole
K36	K36	K36	K36	K36
	V38	V38	V38	V38
			L39
	D40
S41
			V43
	L52	L52	L52	L52
		N54^a	N54
L55	L55^a	L55^a	L55^a	L55^a
T56	T56	T56	T56	T56
G57	G57	G57	G57	G57
	T58		T58
G65			G65	G65
I72	I72	I72	I72	I72
C73	C73	C73	C73^a	C73
L74	L74	L74	L74	L74
W75		W75	W75
C87		C87	C87
	F88		F88	F88
	V89	V89	V89	V89
K90	K90		K90^a	K90^a
	S93		S93	S93
		T96^a	T96^a
		I97
		K98	K98	K98
			T99^a	T99^a
G100	G100		G100	G100
			K101^a
			H102^a	H102^a
G107	G107	G107	G107	G107
	K108	K108	K108
I109
			F135^a	F135^a
			D137	D137
		E138		E138^a
				V141^a
				F142
			S143	S143

Prazole binding was determined by NMR. Residues that were broadened beyond detection upon addition of ligand are indicated by superscript (^a). Bold font indicates affected residues common to all drugs tested.

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