Table 1 Baseline demographics of DLBCL patients and prevalence of comorbidities at diagnosis (SD – standard deviation; NA – not available).
Number of patients (frequency) | |||||||
|---|---|---|---|---|---|---|---|
All patients | Patients with DM2 | p | Patients with HF | p | Patients without analyzed comorbidities | p | |
Number of patients | 469 | 76 | — | 46 | — | 373 | — |
Sex | 0.45 | 1 | 0.91 | ||||
Female | 245 (52.2%) | 43 (56.6%) | 24 (52.2%) | 194 (52%) | |||
Male | 224 (47.8%) | 33 (43.4%) | 22 (47.8%) | 179 (48%) | |||
Age | 57 (18–86) | 69 (47–86) | <0.0001 | 71 (33–85) | <0.0001 | 53 (18–86) | <0.0001 |
Rituximab | 0.2 | 0.6 | 0.25 | ||||
Yes | 424 (90.4%) | 72 (94.7%) | 43 (93.5%) | 334 (89.5%) | |||
No | 45 (9.6%) | 4 (5.3%) | 3 (6.5%) | 39 (10.5%) | |||
Stage | 0.66 | 0.15 | 0.69 | ||||
I | 17 (3.6%) | 4 (5.3%) | 3 (6.5%) | 13 (3.5%) | |||
II | 96 (20.5%) | 16 (21%) | 4 (8.7%) | 79 (21.2%) | |||
III | 118 (25.1%) | 20 (26.3%) | 12 (26.1%) | 93 (24.9%) | |||
IV | 238 (50.8%) | 36 (47.4%) | 27 (58.7%) | 188 (50.4%) | |||
General symptoms | 0.42 | 0.25 | 1 | ||||
Present | 313 (66.7%) | 47 (61.8%) | 34 (73.9%) | 249 (66.8%) | |||
Absent | 150 (32%) | 27 (35.5%) | 11 (23.9) | 120 (32.2%) | |||
Missing | 6 (1.3%) | 2 (2.6%) | 1 (2.2%) | 4 (1%) | |||
IPI | 0.088* | 0.00005* | 0.0024* | ||||
0 | 16 (3.4%) | 2 (2.6%) | 2 (4.3%) | 14 (3.8%) | |||
1 | 76 (16.2%) | 9 (11.9%) | 2 (4.3%) | 66 (17.7%) | |||
2 | 115 (24.5%) | 17 (22.4%) | 4 (8.7%) | 97 (26%) | |||
3 | 126 (26.9%) | 20 (26.3%) | 14 (30.4%) | 100 (26.8%) | |||
4 | 75 (16.0%) | 20 (26.3%) | 17 (37%) | 47 (12.6) | |||
5 | 8 (1.7%) | 2 (2.6%) | 2 (4.3%) | 6 (1.6%) | |||
Missing | 53 (11.3%) | 6 (7.9%) | 5 (11%) | 43 (11.5) | |||
Median | 3 | 3 | 3 | 2 | |||
Mean ± SD | 2.5 ± 1.2 | 2.8 ± 1.2 | 3.2 ± 1.2 | 2.4 ± 1.1 | |||
Type 2 diabetes mellitus | 76 (16.2%) | — | — | 26 (56.5%) | <0.0001 | 0 (0%) | <0.0001 |
Pre-existing heart failure | 46 (9.8%) | 26 (34.2%) | <0.0001 | — | — | 0 (0%) | <0.0001 |
Lipid abnormalities | 69 (14.7%) | 21 (27.6%) | 0.0011 | 15 (32.6%) | 0.0013 | 43 (11.5%) | 0.00028 |
Obesity | 88 (18.8%) | 21 (27.6%) | 0.034 | 10 (21.7%) | 0.56 | 62 (16.6%) | 0.018 |
Smoking | 88 (18.8%) | 14 (18.4%) | 1 | 8 (17.4%) | 1 | 70 (18.8%) | 0.88 |
Arterial hypertension | 176 (37.5%) | 59 (77.6%) | <0.0001 | 18 (39.1%) | <0.0001 | 105 (28.2%) | <0.0001 |
Nephropathy | NA | — | — | NA | — | ||
Present | 15 (20%) | 5 (11%) | |||||
Absent | 53 (70%) | 17 (37%) | |||||
Missing | 8 (11%) | 24 (52%) | |||||
