Table 3 Prognostic factors of overall survival and progression-free survival based upon univariate analysis presented as hazard ratios with 95% confidence intervals.

From: Type 2 diabetes mellitus compromises the survival of diffuse large B-cell lymphoma patients treated with (R)-CHOP – the PLRG report

Variable

Overall survival

HR (95% CI)

p

Rituximab (yes vs no)

1.51 (0.7–3.2)

0.28

Sex (male vs female)

1.1 (0.7–1.8)

0.66

Lymphoma stage

I, II vs III, IV

3.1 (1.5–6.4)

0.003

Age (as a categorical value)

(>50 and ≤60) vs <50

>60 vs <50

1.2 (0.6–2.3)

2.1 (1.2–3.6)

0.57

0.01

IPI

1–2 vs 3–5

2.5 (1.4–4.3)

0.001

Type 2 diabetes mellitus

1.9 (1.2–3.2)

0.01

Pre-existing HF

2.5 (1.4–4.4)

0.002

Hypertension

1 (0.6–1.6)

0.95

Lipid abnormalities

0.8 (0.4–1.6)

0.44

Obesity

0.9 (0.5–1.6)

0.76

Smoking

1.1 (0.6–1.9)

0.69

 

Progression-free survival

Rituximab (yes vs no)

0.85 (0.5–1.4)

0.53

Sex (male vs female)

1.25 (0.9–1.8)

0.23

Lymphoma stage

I, II vs III, IV

2.5 (1.5–4.3)

<0.001

Age (as a categorical value)

(>50 and ≤60) vs <50

>60 vs <50

1.0 (0.6–1.6)

1.3 (0.9–2.0)

1.0

0.16

IPI

1–2 vs 3–5

2.7 (1.8–4.1)

<0.001

Type 2 diabetes mellitus

1.6 (1.03–2.4)

0.036

Pre-existing HF

1.9 (1.1–3.1)

0.014

Hypertension

1.0 (0.7–1.5)

0.83

Lipid abnormalities

0.9 (0.5–1.7)

0.77

Obesity

0.8 (0.5–1.3)

0.43

Smoking

1.3 (0.8–1.9)

0.28