Table 3 Evaluation of the dilution integrity of DSV, TAM, and TOH in rat plasma.

From: Development and validation of UPLC-MS/MS method for studying the pharmacokinetic interaction of dasabuvir and tamoxifen, 4-hydroxytamoxifen in Wistar rats

 

Concentration spiked (ng/mL)

Dilution fold

Mean recovery (%) ± RSDa

Er(%)b

DSV

2000

1:2

98.09 ± 2.69

−1.91

  

1:5

99.74 ± 3.96

−0.26

TAM

1000

1:2

98.07 ± 1.58

−1.93

  

1:5

96.11 ± 2.53

−3.89

TOH

1000

1:2

97.15 ± 1.64

−2.85

  

1:5

95.44 ± 0.78

−4.56

  1. aMean recovery (%) ± RSD of six determinations.
  2. bPercentage relative error.
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