Figure 6 | Scientific Reports

Figure 6

From: Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery

Figure 6The alternative text for this image may have been generated using AI.

Integrated metabolic pathway enrichment analysis. (a) Gene-metabolite joint pathways were identified using the MetaboAnalyst integrated pathway analysis module. (b) Gene-metabolite network exploration identified a GOT1- and GOT2-mediated interactive network that might influence the TCA cycle and other metabolic pathways. (c–e) Box plots of GOT1 expression in malignant prostate tumor compared to normal (data sources https://www.oncomine.org/resource/login.html). (f) A bar graph of GOT1 expression across the prostate cancer Gleason score (GS) (data sources GSE30521). (g–i) A volcano plots of the differential metabolites (g), bar graph of glutamate level among normal, tumor, and metastatic clinical specimens of Pan-Cancer Metabolism Data Explorer (h), and ROC curve for glutamate level prediction in PCa urine samples compared to normal (i). Statistical significance was analyzed by Student’s t-test.

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