Figure 3
From: Suppression of antibiotic resistance evolution by single-gene deletion
Genes whose deletion significantly suppresses resistance evolution. (a) Venn diagram representing genes whose deletion resulted in significantly lower IC50 values for the indicated drugs (Cefixime; CFIX, Ciprofloxacin; CPFX, Chloramphenicol; CP) on the last day of laboratory evolution in comparison with the wild-type strain BW25113 (without gene deletion). The genes with FDR (calculated by Benjamini-Hochberg method) <0.1 are presented. (b–g) The time courses of IC50 for ΔarcA (b–g) and ΔgutM (e–g) in the laboratory evolution with the three indicated drugs.
