Figure 6

PPI network, significant module, and hub gene network constructed by STRING and Cytoscape. (A) There were 539 edges and 225 nodes in the PPI network. (B) The first module consists of 45 edges and 10 nodes. (C) The second module consists of 21 edges and 7 nodes. (D) The third module consists of 13 edges and 6 nodes. (E) The fourth module consists of 10 edges and 5 nodes. (F) The fifth module consists of 6 edges and 4 nodes. (G) The sixth module consists of 20 edges and 12 nodes. (H) A total of 10 genes were identified as hub genes with Cytoscape: OPRL1, CCL5, IL10, IGF1, CCL4, SST, GRM1, PVALB, CXCL13, and NTS.