Figure 2
From: Longitudinal DNA methylation differences precede type 1 diabetes
The most statistically significant of 10 differentially changing methylation regions (DCMRs) associated with development of T1D. (a) Methylation (%, Beta) in longitudinal samples from T1D cases (orange) and controls (blue) from the 450 K (open circle) and EPIC (solid circle) for the most statistically significant DCMP involved in the DCMR (cg09118625). The regression line shows average longitudinal methylation over time from the 450 K (solid) and EPIC (dotted) for each group. The meta estimated slope for cases = 1.2% and controls = 2.6%. (b) The change in meta beta per year is shown for T1D cases (orange) and controls (blue) across all seven probes in the DCMR on chromosome 1, located near both GNG12-AS1 and DIRAS3. (c) Structure of GNG12-AS1 and DIRAS3 isoforms from Ensembl are displayed, including: exons (boxes) and introns (lines). The arrow indicates the direction of transcription. The black box above the transcript structures represents the zoomed in region where the probes involved in the DCMR are located. The red line on the ideogram at the bottom shows on a chromosomal level where the DCMR is located.
