Table 3 Heterosubtypic protection against lethal PR8 influenza virus in mice by prime-boost strategy based on M1 vaccine.

From: Immunization with DNA prime-subunit protein boost strategy based on influenza H9N2 virus conserved matrix protein M1 and its epitope screening

Group

Immunogen

Survival rate (No. Of survivors/no. tested)

A

100 μg DNA+100 μg M1

5/10a

D

100 μg M1

0/10

H

Control

0/10

  1. Mice of three groups were immunized as described above. Two weeks after the last immunization, mice were challenged with a lethal dose (5 × LD50) of influenza heterosubtypic virus PR8. The survival rate of mice 21 days post-infection was determined.
  2. aSignificant differences compared to the mice in control group (p < 0.05).
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