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Figure 1

From: High-Dose Melatonin and Ethanol Excipient Combined with Therapeutic Hypothermia in a Newborn Piglet Asphyxia Model

Figure 1

Study time-line. Following baseline data acquisition, piglets underwent cerebral HI. At the end of HI (time t = 0), piglets were randomized to (i) HT (33.5 °C) from 1–13 h with saline bolus at 1–3 and 25–27 h or (ii) HT+vehicle (HT+V; 2.5% ethanol); (iii) HT+melatonin (HT+M;18 mg/kg dissolved in 2.5% ethanol) at 1–3 and 25–27 h. Intensive care support was given for 48 h following HI. aEEG/continuous video EEG was acquired. MRI/MRS was performed at 3 T at 24 and 48 h. The experiment was terminated at 48 h and brain immunohistochemistry analyzed.

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