Figure 3
Amplitude-integrated electroencephalogram (aEEG) background activity at baseline, during HI and following HI. The grouped mean hourly aEEG scores per 6 h period with 95% Least Significant Difference (LSD) are shown. Non-overlapping bars show evidence of a significant difference. The mean hourly aEEG scores were significantly higher in the HT+M group versus HT+V and HT from 19–24 h (p = 0.037 and p = 0.025 respectively) and 25–30 h (p = 0.022 and p = 0.010 respectively) after HI, indicating faster recovery of brain electrical activity. From 31 h onwards, the vehicle treated group’s brain electrical activity recovered and there was no difference between the HT+M and HT+V groups. The aEEG background voltage did not recover in the HT group and was significantly lower than both HT+V and HT+M groups, with scores of <1 from 31 h until the end of the study. *Shows when the HT+M group aEEG recovered compared to HT+V and HT groups. #Shows when the HT+V group aEEG recovered compared to the HT group.
