Table 1 Physiological parameters for the piglets in each group.
Parameter | HT LS Mean (SEM) | HT+Vehicle LS Mean (SEM) | HT+Melatonin LS Mean (SEM) | P value |
|---|---|---|---|---|
Weight (kg) | 2.1 (0.05) | 2.1 (0.04) | 2.0 (0.05) | 0.776 |
Hypoxic ischemic insult | ||||
Duration of HI insult (min) | 21.3 (1.1) | 20.0 (1.0) | 23.1 (1.0) | 0.103 |
Duration of isoelectric EEG during HI (min) | 19 (0.08) | 18.3 (0.8) | 20.9 (0.8) | 0.081 |
Duration of blood pressure <30 mmHg (min) | 8.7 (1.4) | 10.7 (1.3) | 6.9 (1.3) | 0.150 |
Duration of blood pressure <25 mmHg (min) | 2.3 (1.2) | 3.2 (1.1) | 0.7 (1.1.) | 0.321 |
Nadir pH | 7.2 (0.03) | 7.2 (0.03) | 7.2 (0.03) | 0.433 |
Nadir Lactate (mmol/l) | 14.3 (0.7) | 11.9 (0.7) | 13.3 (0.7) | 0.070 |
Area under the curve FiO2 | 287.2 (19.6) | 271.6 (18.2) | 322.4 (18.2) | 0.160 |
Nadir base excess (mmol/l) | −13.2 (2.94) | −9.7 (1.2) | −9.6 (1.2) | 0.103 |
Heart rate (min−1) | ||||
Baseline | 179.9 (8.2) | 166.2 (7.6) | 175.4 (7.6) | 0.471 |
0–1 h after insult | 200 (10.0) | 197.6 (9.2) | 192.6 (9.2) | 0.857 |
1–13 h | 181.8 (6.82) | 171.3 (6.3) | 171.0 (6.3) | 0.445 |
13–25 h | 202 (11.5) | 195.6 (10.6) | 181.4 (10.6) | 0.416 |
25–48 h | 212.4 (9.4) | 182.1 (7.9) | 187.1 (7.9) | 0.061 |
Mean arterial blood pressure (mmHg) | ||||
Baseline | 52 (2.6) | 51.2 (2.4) | 50.2 (2.4) | 0.875 |
0–1 h after insult | 53.3 (5.0) | 44.3 (4.6) | 45.4 (4.6) | 0.384 |
1–13 h | 46 (1.6) | 42.4 (1.5) | 45.8 (1.5) | 0.191 |
13–25 h | 45.8 (2.5) | 42.6 (2.3) | 50.3 (2.3) | 0.091 |
25–48 h | 55.0 (2.1) | 49.4 (1.8) | 52.6 (1.8) | 0.152 |
Rectal temperature (°C) | ||||
Baseline | 38.1 (0.3) | 38.3 (0.3) | 38.0 (0.3) | 0.777 |
0–1 h after insult | 38.9 (0.2) | 38.5 (0.1) | 38.2 (0.1) | 0.020 |
1–13 h | 34.0 (0.05) | 34 (0.05) | 33.9 (0.05) | 0.615 |
13–25 h | 36.2 (0.1) | 36.5 (0.1) | 36.4 (0.1) | 0.295 |
25–48 h | 38.4 (0.09) | 38.5 (0.08) | 38.4 (0.08) | 0.794 |
PaO2 (kPa) | ||||
Baseline | 11.1 (1.3) | 9.9 (1.2) | 14.2 (1.2) | 0.067 |
End of insult (time 0) | 9.3 (1.2) | 6.4 (1.1) | 7.6 (1.1) | 0.241 |
12 h after time 0 | 11.5 (1.0) | 11.3 (0.9) | 10.8 (0.9) | 0.879 |
24 h after time 0 | 11.5 (1.0) | 11.4 (0.9) | 12.8 (0.9) | 0.469 |
48 h after time 0 | 14.1 (0.7) | 12.0 (0.6) | 12.7 (0.6) | 0.119 |
PaCO2 (kPa) | ||||
Baseline | 5.6 (0.4) | 6 (0.4) | 5.4 (0.4) | 0.506 |
End of insult (time 0) | 5.6 (0.4) | 6.1 (0.4) | 6 (0.4) | 0.628 |
12 h after time 0 | 4.8 (0.5) | 5.4 (0.5) | 5.6 (0.5) | 0.521 |
24 h after time 0 | 7 (0.3) | 5.6 (0.3) | 5.5 (0.3) | 0.003 |
48 h after time 0 | 5 (0.3) | 4.5 (0.3) | 5.2 (0.3) | 0.311 |
Blood pH | ||||
pH_Baseline | 7.4 (0.03) | 7.4 (0.03) | 7.5 (0.03) | 0.301 |
End of insult (time 0) | 7.2 (0.04) | 7.2 (0.03) | 7.2 (0.03) | 0.960 |
12 h after time 0 | 7.5 (0.04) | 7.5 (0.03) | 7.5 (0.03) | 0.641 |
24 h after time 0 | 7.3 (0.03) | 7.4 (0.02) | 7.5 (0.02) | 0.009 |
48 h after time 0 | 7.5 (0.02) | 7.5 (0.02) | 7.5 (0.02) | 0.743 |
Base excess (mmol/l) | ||||
Baseline | 1.8 (1.7) | 3.3 (1.6) | 5.4 (1.6) | 0.319 |
End of insult (time 0) | −10.0 (1.7) | −9.7 (1.6) | −9.6 (1.6) | 0.982 |
12 h after time 0 | 5.7 (1.5) | 4.7 (1.4) | 5.7 (1.4) | 0.845 |
24 h after time 0 | 2.2 (2.6) | −0.4 (2.2) | 5.1 (2.2) | 0.222 |
48 h after time 0 | 2.8 (1.3) | 1.9 (1.1) | 3.1 (1.1) | 0.689 |
Lactate (mmol/l) | ||||
Baseline | 5.2 (0.7) | 3.8 (0.7) | 4.1 (0.7) | 0.347 |
End of insult (time 0) | 12.9 (1.0) | 12.3 (0.9) | 13.3 (0.9) | 0.756 |
12 h after time 0 | 3.1 (0.6) | 3.9 (0.6) | 3.1 (0.6) | 0.543 |
24 h after time 0 | 3.3 (1.5) | 5.3 (1.3) | 2.1 (1.3) | 0.227 |
48 h after time 0 | 1.2 (0.3) | 1.7 (0.2) | 1.5 (0.2) | 0.425 |
Glucose (mmol/l) | ||||
Baseline | 6.4 (0.5) | 6 (0.5) | 5.6 (0.5) | 0.493 |
End of insult (time 0) | 9.3 (1.1) | 9.2 (1.0) | 9.7 (1.2) | 0.942 |
12 h after time 0 | 15.2 (1.6) | 13.3 (1.5) | 11.3 (1.5) | 0.254 |
24 h after time 0 | 17 (3.9) | 13.2 (3.3) | 8.9 (3.3) | 0.307 |
48 h after time 0 | 7.2 (1.0) | 6.4 (0.9) | 6 (0.9) | 0.657 |
