Figure 1
From: Anterior retrosplenial cortex is required for long-term object recognition memory
Functional dissociation between the anterior retrosplenial cortex and the dorsal hippocampus in the “what” memory component processing. (a) Schematic representation of infusions and the Y-maze object recognition (Y-OR) behavioral paradigm. (b,c) Animals were infused with Muscimol (Mus, gray bar) or Vehicle (Veh, white bar) into the anterior retrosplenial cortex (aRSC) (b) or dorsal hippocampus (dHP) (c) immediately after sample phase; the choice phase was performed 24 h later. Data are expressed as memory index mean ± SEM. **p < 0.01 Mus vs. Veh; Two-tailed Student’s t-test. (b) n = 8 per group, (c) n = 4–5. (d) Schematic representation of the behavioral protocol. (e,f) Percentage of c-Fos in the aRSC (e) and the dHP (f) of naïve animals (N, white bar), and animals subjected to the empty context (c, light gray bar) or to the sample phase (S, gray bar) 1 h after the Y-OR. Representative blots are shown below each graphic. Data are expressed as mean ± SEM of c-Fos percentage respect to naïve. ***p < 0.005, Bonferroni Multiple Comparison Test after two-way ANOVA. (e) n = 4, (f) n = 3–5.
