Figure 2
From: NBIA: a network-based integrative analysis framework – applied to pathway analysis
Number of significant pathways and their ranking in Alzheimer’s disease (panel A), influenza (panel B), and AML (panel C) using 10 meta-analysis approaches. The horizontal axis shows the ranking of the pathways while the vertical axis shows the 10 methods. The significance threshold is consistently set to 5% for all approaches. For each method, we draw a segment that represents the range of the significant pathways. For all of the three diseases, MetaPath finds no significant pathway at the significance cutoff of FDR = 5%. The 6 GSA-, GSEA-, and IA-based methods generally identify large sets of significant pathways, among which many are likely to be false positives. NBIA consistently identifies the target pathways as significant and ranks them on top in each of the three conditions.
