Table 1 The top 10 ranked pathways and FDR-corrected p-values obtained by combining Alzheimer’s data using NBIA. The horizontal line represents the cutoff of 5%. All of the three target pathways are ranked on top with FDR-adjusted p-values smaller than 5%.
From: NBIA: a network-based integrative analysis framework – applied to pathway analysis
NBIA | ||
|---|---|---|
Pathway | p.fdr | |
1 | Parkinson’s disease | 7e-07 |
2 | Alzheimer’s disease | 0.0024 |
3 | Huntington’s disease | 0.0086 |
4 | Glutamatergic synapse | 0.1008 |
5 | Amyotrophic lateral sclerosis (ALS) | 0.1750 |
6 | Sphingolipid signaling pathway | 0.2137 |
7 | Regulation of actin cytoskeleton | 0.2137 |
8 | Synaptic vesicle cycle | 0.3868 |
9 | Retrograde endocannabinoid signaling | 0.6446 |
10 | Fc gamma R-mediated phagocytosis | 0.6446 |
