Figure 5 | Scientific Reports

Figure 5

From: Metabolomic-guided discovery of cyclic nonribosomal peptides from Xylaria ellisii sp. nov., a leaf and stem endophyte of Vaccinium angustifolium

Figure 5

Ellisiiamides A–H (12–19), new cyclic nonribosomal peptides from Xylaria ellisii. (a) ellisiiamides A–C (12–14) isolated and characterized by 1D and 2D NMR, LC-HRHMS and LC-HRMS/MS analysis with new amino acid substituent highlighted. Corresponding COSY/TOCSY (1H -1H), HMBC (1H-13C) and long-range through-space NOESY/ROESY correlations are shown. (b) Structures of ellisiiamides D–H (15–19) based on LC-MS/MS, comparative LC-MS/MS analysis of cyclic pentapeptides 9, 11 and 12–14 (c) Amino acid scaffold of the cyclic pentapeptide family of compounds. Cyclic pentapeptide 1 (9) shown with established amino acid substituents.

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