Figure 5

The frequency of known miRNAs among total clean reads of small RNAs. (A) The frequency of known miRNAs in serum sEVs from human, rat and mouse, human vs. rat, **P = 0.0035; human vs. mouse, ***P = 0.0002; rat vs. mouse, *P = 0.0458; de-sEV serum, human vs. rat, **P = 0.0019; human vs. mouse, **P = 0.0039; rat vs. mouse, ns, P = 0.2693. (B) The frequency of known miRNAs in serum sEVs vs. de-sEV serum, human, *P = 0.014; rat, *P = 0.0103; mouse, *P = 0.0399. sEV, small extracellular vesicle; de-sEV, small extracellular vesicle depleted.